Katia Koelle , Interpandemic Influenza A ( H 3 N 2 ) in Humans Epochal
نویسنده
چکیده
. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of September 30, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/314/5807/1898 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/314/5807/1898/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/314/5807/1898#related-content http://www.sciencemag.org/cgi/content/full/314/5807/1898#otherarticles , 19 of which can be accessed for free: cites 44 articles This article 60 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/314/5807/1898#otherarticles 21 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/epidemiology Epidemiology : subject collections This article appears in the following
منابع مشابه
Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans.
Human influenza A (subtype H3N2) is characterized genetically by the limited standing diversity of its hemagglutinin and antigenically by clusters that emerge and replace each other within 2 to 8 years. By introducing an epidemiological model that allows for differences between the genetic and antigenic properties of the virus's hemagglutinin, we show that these patterns can arise from cluster-...
متن کاملInterpandemic Influenza A ( H 3 N 2 ) in Humans Epochal
. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of April 6, 2010 ): The following resources related to this article are available online at www.s...
متن کاملPhylodynamic Inference and Model Assessment with Approximate Bayesian Computation: Influenza as a Case Study
A key priority in infectious disease research is to understand the ecological and evolutionary drivers of viral diseases from data on disease incidence as well as viral genetic and antigenic variation. We propose using a simulation-based, Bayesian method known as Approximate Bayesian Computation (ABC) to fit and assess phylodynamic models that simulate pathogen evolution and ecology against sum...
متن کاملLimited effective reassortment shapes influenza dynamics in a human host
Limited effective reassortment shapes influenza dynamics in a human host Ashley Sobel Leonard, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, Timothy B. Stockwell, Suman R. Das, Anthony S. Gilbert, Rob Lambkin-Williams, Geoffrey S. Ginsburg, Christopher W. Woods, Katia Koelle, Christopher J. R. Illingworth6,7∗ 1 Department of Biology, Duke U...
متن کاملThe effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans
Recent phylogenetic analyses indicate that RNA virus populations carry a significant deleterious mutation load. This mutation load has the potential to shape patterns of adaptive evolution via genetic linkage to beneficial mutations. Here, we examine the effect of deleterious mutations on patterns of influenza A subtype H3N2's antigenic evolution in humans. By first analyzing simple models of i...
متن کامل